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Honors & awards

Second Prize of the National Science and Technology Progress Award Commemorative Medal for the 70th Anniversary of the Founding of the People's Republic of China First Prize of the Liaoning Province Science and Technology Progress Award First Prize of the Dalian City Science and Technology Progress Award

Research achievement

Clam Breeding Science Clam Aquaculture Science Reproductive Biology of Intertidal Mollusks in Liaoning

Cultivated 3 nationally approved new aquatic species

New Clam Variety "Zebra Clam II" (GS-01-007-2021) New Clam Variety "White Zebra Clam" (GS-01-009-2016) New Clam Variety "Zebra Clam" (GS-01-006-2014)

Published papers


Wang, J., Hu, J., Xu, Q., Chen, S., Bi, J., Huo, Z., Yan, X., & Nie, H. (2024). Extraction of melanin from the shell and mantle and activities of enzymes related to the melanin biosynthesis in the Ruditapes philippinarum. Aquaculture and Fisheries.
Tan, Y., Liu, L., Zhang, Y., Fang, L., Liu, Y., & Huo, Z. (2024). Geographic patterns and ecological adaptations of Manila clam (Ruditapes philippinarum) along the Chinese coast: Insights from migration dynamics and gene flow. Global Ecology and Conservation.
Zhang, Y., Nie, H., Huo, Z., & Yan, X. (2024). Heat hardening enhances the energy metabolism activity and oxidative defense ability of Manila clam Ruditapes philippinarum under different thermal stress. Aquaculture.
Liu, T., Nie, H., Ding, J., Huo, Z., & Yan, X. (2024). Physiological and transcriptomic analysis provides new insights into osmoregulation mechanism of Ruditapes philippinarum under low and high salinity stress. The Science of the total environment, 935, 173215. DOI Link
Huo, Z., Wang, Z., Li, D., Liu, K., Li, X., Fang, L., & Yan, X. (2024). Shell shape polymorphism analysis of the Manila clam Ruditapes philippinarum across different geographical populations in China. Frontiers in Marine Science.
Li, M., Liu, X., Li, D., Ding, J., Yang, F., Huo, Z., & Yan, X. (2024). The energy metabolism and transcriptomic responses of the Manila clam (Ruditapes philippinarum) under the low-temperature stress. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 51, 101259. DOI Link
Wang, Y., Dongdong, L., Zhang, H., Chen, J., Tang, Y., Nie, H., Huo, Z., & Yan, X. (2024). Transcriptome analysis of Manila clam (Ruditapes philippinarum) under Vibrio parahaemolyticus challenge in a low-salinity environment provides molecular insights into immune response. Aquaculture.
Li, H., Nie, H., Li, D., Wang, B., Huo, Z., Su, Y., & Yan, X. (2024). Transcriptome analysis provides new insights into the immune response of Ruditapes philippinarum infected with Vibrio alginolyticus. Fish & shellfish immunology, 148, 109468.DOI Link
Qin, L., Zhao, W., Gu, J., Li, Y., Liu, Y., & Huo, Z. (2023). Annual variations in the nutritional quality of the Geoduck clam Panopea japonica. Journal of Food Composition and Analysis.
Luo, X., Che, Z., Su, C., Wang, H., Sun, Y., Li, D., Yang, F., Huo, Z., Su, Y., & Yan, X. (2023). Embryonic development, survival and growth of triploid Zebra Clam II strain of the Manila clam Ruditapes philippinarum. Aquaculture Reports.
Liu, J., Nie, H., Huo, Z., & Yan, X. (2023). Genome-Wide Identification and Characterization of MITF Genes in Ruditapes philippinarum and Their Involvement in the Immune Response to Vibrio anguillarum Infection. Biochemical genetics, 61(6), 2514–2530. DOI Link
Zhang, Z., Wang, J., Huo, Z., Nie, H., Yan, X., & Ding, J. (2023). Identification and expression of cysteine sulfite decarboxylase genes and their response to hyposalinity stress in Ruditapes philippinarum. Frontiers in Marine Science.
Zheng, Z., Huo, Z., Huang, K., Jiang, M., Yan, X., Liu, Y., & Qin, Y. (2023). Metabolic adaptation of the clam Ruditapes philippinarum during air exposure and the positive effects of sodium nitroprusside pretreatment. Frontiers in Physiology, 14.
Jahan, K., Nie, H., & Yan, X. (2023). Revealing the potential regulatory relationship between HSP70, HSP90 and HSF genes under temperature stress. Fish & shellfish immunology, 108607 .
Chen, S., Nie, H., Huo, Z., & Yan, X. (2023). Transcriptional profiling of pigmentation-regulated long non-coding RNAs in the mantle of Manila clam (Ruditapes philippinarum). Aquaculture.
Chen, S., Nie, H., Huo, Z., & Yan, X. (2023). Comprehensive analysis of differentially expressed mRNA, lncRNA and miRNA, and their ceRNA networks in the regulation of shell color in the Manila clam (Ruditapes philippinarum). International journal of biological macromolecules, 128404 .
Zhang, Y., Nie, H., Yin, Z. et al. Comparative transcriptomic analysis revealed dynamic changes of distinct classes of genes during development of the Manila clam (Ruditapes philippinarum). BMC Genomics 23, 676 (2022). DOI Link
Yu, J., Yin, Z., Zhang, Y., Bi, J., Yan, X., & Nie, H. (2022). Effects of high water temperature on physiology, survival, and resistance to high temperature air-exposure in the Manila clam Ruditapes philippinarum. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 262, 109469. DOI Link
Yin, Z., Wang, Z., Zhang, Y., Yin, X., Yan, X., Wang, B., & Nie, H. (2022). Examination of the potential roles of insulin-like peptide receptor in regulating the growth of Manila clam Ruditapes philippinarum. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 274, 111315. DOI Link
Tang, Y., Huo, Z., Liu, Y., Wang, Y., Zuo, L., Fang, L., Zhao, W., Tan, Y.Y., & Yan, X. (2022). Full Mitochondrial Genomes Reveal Species Differences between the Venerid Clams Ruditapes philippinarum and R. variegatus. Genes, 13.
Lin, Z., Nie, H., Zhang, Y., Yin, Z., & Yan, X. (2022). Genome-wide identification and analysis of HECT E3 ubiquitin ligase gene family in Ruditapes philippinarum and their involvement in the response to heat stress and Vibrio anguillarum infection. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 43, 101012. https://doi.org/10.1016/j.cbd.2022.101012
Yin, Z., Nie, H., Jiang, K., & Yan, X. (2022). Molecular Mechanisms Underlying Vibrio Tolerance in Ruditapes philippinarum Revealed by Comparative Transcriptome Profiling. Frontiers in immunology, 13, 879337. DOI Link
Nie, H., Lu, Z., Li, D., Dong, S., Li, N., Chen, W.S., Huo, Z., & Yan, X. (2022). The potential roles of fatty acid metabolism-related genes in Manila clam Ruditapes philippinarum under cold stress. Aquaculture.
Wang, F., Li, C., Zhao, W. et al. Toxicity of ammonia to larvae and juveniles of the geoduck clam Panopea japonica. Fish Sci 88, 311–317 (2022). DOI Link
Ma, Q., Shi, W., Jahan, K., Zhao, W., Xu, Q., Huo, Z., Fang, L., Yang, F., & Yan, X. (2022). Transcriptome sequencing reveals improved ammonia nitrogen tolerance in Zebra II strain of the Manila clam Ruditapes philippinarum. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 44, 101016 .
Dong S, Wang C, Nie H, et al. Type II ice structuring protein (ISP II) gene and its potential role in low temperature tolerance in Manila clam, Ruditapes philippinarum Aquaculture.. 2022 Feb;549:Not Available. DOI: 10.1016/j.aquaculture.2021.737723.
Jiang, K., Yin, Z., Zhang, Y., Xu, Q., Yu, Y., Cong, W., Yan, X., & Nie, H. (2021). Genome-wide investigation and expression analysis of MACPF gene family reveals its immune role in response to bacterial challenge of Manila clam. Genomics, 113(3), 1136–1145. DOI Link
Ding, J., Wen, Q., Huo, Z., Nie, H., Qin, Y., & Yan, X. (2021). Identification of shell-color-related microRNAs in the Manila clam Ruditapes philippinarum using high-throughput sequencing of small RNA transcriptomes. Scientific reports, 11(1), 8044. DOI Link
Wang, Z., Bai, Y., Nie, H., Xu, Q., Yin, Z., Zhang, Y., Yin, X., & Yan, X. (2021). Molecular mechanisms of wound healing and regeneration of siphon in the Manila clam Ruditapes philippinarum revealed by transcriptomic analysis. Genomics.
Nie, H., Zheng, M., Wang, Z., Xu, Q., Yin, Z., Zhang, Y., & Yan, X. (2021). Transcriptomic analysis provides insights into candidate genes and molecular pathways involved in growth of Manila clam Ruditapes philippinarum. Functional & integrative genomics, 21(3-4), 341–353. DOI Link
Liu, J., Sun, X., Nie, H., Kifat, J., Li, J., Huo, Z., Bi, J., & Yan, X. (2021). Genome-wide identification and expression profiling of TYR gene family in Ruditapes philippinarum under the challenge of Vibrio anguillarum. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 37, 100788. DOI Link
Wang, J., Zhang, H., Xu, S., Liu, Z., Yang, L., Fang, L., Huo, Z., & Yan, X. (2021). Characterization of the SIRT genes and their distinct expression patterns in Manila clams (Ruditapes philippinarum) exposed to air. Meta Gene, 100892.
Zhao, W.X., Li, Y., Wang, Y., Luo, X., Wu, Q., Huo, Z., Song, J., & Yan, X. (2021). Gonadal development and the reproductive cycle of the geoduck clam (Panopea japonica) in the Sea of Japan. Aquaculture.
Dong S, Wang C, Nie H, et al. Type II ice structuring protein (ISP II) gene and its potential role in low temperature tolerance in Manila clam, Ruditapes philippinarum Aquaculture.. 2022 Feb;549:Not Available. DOI: 10.1016/j.aquaculture.2021.737723.
Xu, Q., Nie, H., Yin, Z., Zhang, Y., Huo, Z., & Yan, X. (2021). MiRNA-mRNA Integration Analysis Reveals the Regulatory Roles of MiRNAs in Shell Pigmentation of the Manila clam (Ruditapes philippinarum). Marine Biotechnology, 23, 976 - 993.
Li, D., Nie, H., Jahan, K., & Yan, X. (2020). Expression analyses of C-type lectins (CTLs) in Manila clam under cold stress provide insights for its potential function in cold resistance of Ruditapes philippinarum. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 230, 108708. DOI Link
Xu, Q., Zheng, J., Yan, X., & Nie, H. (2020). Genetic diversity and differentiation of nine populations of the hard clam (Meretrix petechialis) assessed by EST-derived microsatellites. Electronic Journal of Biotechnology.
Xu, Q., Zheng, J., Nie, H., Wang, Q., & Yan, X. (2020). Genetic diversity and population structure of Meretrix petechialis in China revealed by sequence-related amplified polymorphism markers. PeerJ, 8, e8723.
Wang, J., Fang, L., Wu, Q., Li, D., Huo, Z., & Yan, X. (2020). Genome-wide identification and characterization of the AMPK genes and their distinct expression patterns in response to air exposure in the Manila clam (Ruditapes philippinarum). Genes & genomics, 42(1), 1–12. DOI Link
Bai, Y., Nie, H., Wang, Z., & Yan, X. (2020). Genome-wide identification and transcriptome-based expression profiling of Wnt gene family in Ruditapes philippinarum. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 35, 100709. DOI Link
Nie, H., Jiang, K., Zhou, Z., Guo, B., Li, D., & Yan, X. (2020). Modulated Expression and Activities of Ruditapes philippinarum Enzymes After Oxidative Stress Induced by Aerial Exposure and Reimmersion. Frontiers in physiology, 11, 500.DOI Link
Li, D., Nie, H., Jiang, K., Li, N., Huo, Z., & Yan, X. (2020). Molecular characterization and expression analysis of fibrinogen related protein (FREP) genes of Manila clam (Ruditapes philippinarum) after lipopolysaccharides challenge. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 228, 108672. DOI Link
Dong, S., Nie, H., Li, D., Cai, Z., Sun, X., Huo, Z., & Yan, X. (2020). Molecular cloning and characterization of Y-box gene (Rpybx) from Manila clam and its expression analysis in different strains under low-temperature stress. Animal genetics, 51(3), 430–438.DOI Link
Jiang, K., Nie, H., & Yan, X. (2020). Molecular cloning and expression analysis of mc5r like genes (mc5rl) in Ruditapes philippinarum (Manila clam) after aerial exposure and low-temperature stress. Molecular biology reports, 47(11), 8891–8901. DOI Link
Jiang, K., Jiang, L., Nie, H., Huo, Z., & Yan, X. (2020). Molecular cloning and expression analysis of tyrosinases (tyr) in four shell-color strains of Manila clam Ruditapes philippinarum. PeerJ, 8, e8641. DOI Link
Jiang, K., Nie, H., Li, D., & Yan, X. (2020). New insights into the Manila clam and PAMPs interaction based on RNA-seq analysis of clam through in vitro challenges with LPS, PGN, and poly(I:C). BMC genomics, 21(1), 531.DOI Link
Nie, H., Jahan, K., Zhang, W., Huo, Z., & Yan, X. (2020). Physiological and biochemical responses of different shell color strains of Manila clam to low salinity challenges. Aquaculture Reports, 16, 100260.
Dong, S., Nie, H., Ye, J., Li, D., Huo, Z., & Yan, X. (2020). Physiological and gene expression analysis of the Manila clam Ruditapes philippinarum in response to cold acclimation. The Science of the total environment, 742, 140427.DOI Link
Tan, Y., Fang, L., Qiu, M. et al. Population genetics of the Manila clam (Ruditapes philippinarum) in East Asia. Sci Rep 10, 21890 (2020). DOI Link
Nie, H., Wang, H., Jiang, K., & Yan, X. (2020). Transcriptome analysis reveals differential immune related genes expression in Ruditapes philippinarum under hypoxia stress: potential HIF and NF-κB crosstalk in immune responses in clam. BMC genomics, 21(1), 318. DOI Link
Nie, H., Jiang, K., Jiang, L., Huo, Z., Ding, J., & Yan, X. (2020). Transcriptome analysis reveals the pigmentation related genes in four different shell color strains of the Manila clam Ruditapes philippinarum. Genomics, 112(2), 2011–2020. DOI Link
Nie, H., Jiang, K., Li, N., Jahan, K., Jiang, L., Huo, Z., & Yan, X. (2021). Transcriptome analysis reveals the pigmentation-related genes in two shell color strains of the Manila clam Ruditapes philippinarum. Animal biotechnology, 32(4), 439–450. DOI Link
Nie H, Jiang K, Li N, Li D, Yan X. Transcriptomic analysis of Ruditapes philippinarum under aerial exposure and reimmersion reveals genes involved in stress response and recovery capacity of the Manila clam Aquaculture.. 2020 Jul;524:Not Available. DOI: 10.1016/j.aquaculture.2020.735271.
Zhao, W., Ma, G., Guo, W., Liu, K., Fang, L., Huo, Z., & Yan, X. (2020). Use of soil pools to prolong the breeding period and culture of the clam, Mactra quadrangularis (Reeve, 1854). Aquaculture Research.

Wang, J., Hu, J., Xu, Q., Chen, S., Bi, J., Huo, Z., Yan, X., & Nie, H. (2024). Extraction of melanin from the shell and mantle and activities of enzymes related to the melanin biosynthesis in the Ruditapes philippinarum. Aquaculture and Fisheries.

Tan, Y., Liu, L., Zhang, Y., Fang, L., Liu, Y., & Huo, Z. (2024). Geographic patterns and ecological adaptations of Manila clam (Ruditapes philippinarum) along the Chinese coast: Insights from migration dynamics and gene flow. Global Ecology and Conservation.

Zhang, Y., Nie, H., Huo, Z., & Yan, X. (2024). Heat hardening enhances the energy metabolism activity and oxidative defense ability of Manila clam Ruditapes philippinarum under different thermal stress. Aquaculture.

Liu, T., Nie, H., Ding, J., Huo, Z., & Yan, X. (2024). Physiological and transcriptomic analysis provides new insights into osmoregulation mechanism of Ruditapes philippinarum under low and high salinity stress. The Science of the total environment, 935, 173215. DOI Link

Huo, Z., Wang, Z., Li, D., Liu, K., Li, X., Fang, L., & Yan, X. (2024). Shell shape polymorphism analysis of the Manila clam Ruditapes philippinarum across different geographical populations in China. Frontiers in Marine Science.

Li, M., Liu, X., Li, D., Ding, J., Yang, F., Huo, Z., & Yan, X. (2024). The energy metabolism and transcriptomic responses of the Manila clam (Ruditapes philippinarum) under the low-temperature stress. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 51, 101259. DOI Link

Wang, Y., Dongdong, L., Zhang, H., Chen, J., Tang, Y., Nie, H., Huo, Z., & Yan, X. (2024). Transcriptome analysis of Manila clam (Ruditapes philippinarum) under Vibrio parahaemolyticus challenge in a low-salinity environment provides molecular insights into immune response. Aquaculture.

Li, H., Nie, H., Li, D., Wang, B., Huo, Z., Su, Y., & Yan, X. (2024). Transcriptome analysis provides new insights into the immune response of Ruditapes philippinarum infected with Vibrio alginolyticus. Fish & shellfish immunology, 148, 109468.DOI Link

Qin, L., Zhao, W., Gu, J., Li, Y., Liu, Y., & Huo, Z. (2023). Annual variations in the nutritional quality of the Geoduck clam Panopea japonica. Journal of Food Composition and Analysis.

Luo, X., Che, Z., Su, C., Wang, H., Sun, Y., Li, D., Yang, F., Huo, Z., Su, Y., & Yan, X. (2023). Embryonic development, survival and growth of triploid Zebra Clam II strain of the Manila clam Ruditapes philippinarum. Aquaculture Reports.

Liu, J., Nie, H., Huo, Z., & Yan, X. (2023). Genome-Wide Identification and Characterization of MITF Genes in Ruditapes philippinarum and Their Involvement in the Immune Response to Vibrio anguillarum Infection. Biochemical genetics, 61(6), 2514–2530. DOI Link

Zhang, Z., Wang, J., Huo, Z., Nie, H., Yan, X., & Ding, J. (2023). Identification and expression of cysteine sulfite decarboxylase genes and their response to hyposalinity stress in Ruditapes philippinarum. Frontiers in Marine Science.

Zheng, Z., Huo, Z., Huang, K., Jiang, M., Yan, X., Liu, Y., & Qin, Y. (2023). Metabolic adaptation of the clam Ruditapes philippinarum during air exposure and the positive effects of sodium nitroprusside pretreatment. Frontiers in Physiology, 14.

Jahan, K., Nie, H., & Yan, X. (2023). Revealing the potential regulatory relationship between HSP70, HSP90 and HSF genes under temperature stress. Fish & shellfish immunology, 108607 .

Chen, S., Nie, H., Huo, Z., & Yan, X. (2023). Transcriptional profiling of pigmentation-regulated long non-coding RNAs in the mantle of Manila clam (Ruditapes philippinarum). Aquaculture.

Chen, S., Nie, H., Huo, Z., & Yan, X. (2023). Comprehensive analysis of differentially expressed mRNA, lncRNA and miRNA, and their ceRNA networks in the regulation of shell color in the Manila clam (Ruditapes philippinarum). International journal of biological macromolecules, 128404 .

Zhang, Y., Nie, H., Yin, Z. et al. Comparative transcriptomic analysis revealed dynamic changes of distinct classes of genes during development of the Manila clam (Ruditapes philippinarum). BMC Genomics 23, 676 (2022). DOI Link

Yu, J., Yin, Z., Zhang, Y., Bi, J., Yan, X., & Nie, H. (2022). Effects of high water temperature on physiology, survival, and resistance to high temperature air-exposure in the Manila clam Ruditapes philippinarum. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 262, 109469. DOI Link

Yin, Z., Wang, Z., Zhang, Y., Yin, X., Yan, X., Wang, B., & Nie, H. (2022). Examination of the potential roles of insulin-like peptide receptor in regulating the growth of Manila clam Ruditapes philippinarum. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 274, 111315. DOI Link

Tang, Y., Huo, Z., Liu, Y., Wang, Y., Zuo, L., Fang, L., Zhao, W., Tan, Y.Y., & Yan, X. (2022). Full Mitochondrial Genomes Reveal Species Differences between the Venerid Clams Ruditapes philippinarum and R. variegatus. Genes, 13.

Lin, Z., Nie, H., Zhang, Y., Yin, Z., & Yan, X. (2022). Genome-wide identification and analysis of HECT E3 ubiquitin ligase gene family in Ruditapes philippinarum and their involvement in the response to heat stress and Vibrio anguillarum infection. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 43, 101012. https://doi.org/10.1016/j.cbd.2022.101012

Yin, Z., Nie, H., Jiang, K., & Yan, X. (2022). Molecular Mechanisms Underlying Vibrio Tolerance in Ruditapes philippinarum Revealed by Comparative Transcriptome Profiling. Frontiers in immunology, 13, 879337. DOI Link

Nie, H., Lu, Z., Li, D., Dong, S., Li, N., Chen, W.S., Huo, Z., & Yan, X. (2022). The potential roles of fatty acid metabolism-related genes in Manila clam Ruditapes philippinarum under cold stress. Aquaculture.

Wang, F., Li, C., Zhao, W. et al. Toxicity of ammonia to larvae and juveniles of the geoduck clam Panopea japonica. Fish Sci 88, 311–317 (2022). DOI Link

Ma, Q., Shi, W., Jahan, K., Zhao, W., Xu, Q., Huo, Z., Fang, L., Yang, F., & Yan, X. (2022). Transcriptome sequencing reveals improved ammonia nitrogen tolerance in Zebra II strain of the Manila clam Ruditapes philippinarum. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 44, 101016 .

Dong S, Wang C, Nie H, et al. Type II ice structuring protein (ISP II) gene and its potential role in low temperature tolerance in Manila clam, Ruditapes philippinarum Aquaculture.. 2022 Feb;549:Not Available. DOI: 10.1016/j.aquaculture.2021.737723.

Jiang, K., Yin, Z., Zhang, Y., Xu, Q., Yu, Y., Cong, W., Yan, X., & Nie, H. (2021). Genome-wide investigation and expression analysis of MACPF gene family reveals its immune role in response to bacterial challenge of Manila clam. Genomics, 113(3), 1136–1145. DOI Link

Ding, J., Wen, Q., Huo, Z., Nie, H., Qin, Y., & Yan, X. (2021). Identification of shell-color-related microRNAs in the Manila clam Ruditapes philippinarum using high-throughput sequencing of small RNA transcriptomes. Scientific reports, 11(1), 8044. DOI Link

Wang, Z., Bai, Y., Nie, H., Xu, Q., Yin, Z., Zhang, Y., Yin, X., & Yan, X. (2021). Molecular mechanisms of wound healing and regeneration of siphon in the Manila clam Ruditapes philippinarum revealed by transcriptomic analysis. Genomics.

Nie, H., Zheng, M., Wang, Z., Xu, Q., Yin, Z., Zhang, Y., & Yan, X. (2021). Transcriptomic analysis provides insights into candidate genes and molecular pathways involved in growth of Manila clam Ruditapes philippinarum. Functional & integrative genomics, 21(3-4), 341–353. DOI Link

Liu, J., Sun, X., Nie, H., Kifat, J., Li, J., Huo, Z., Bi, J., & Yan, X. (2021). Genome-wide identification and expression profiling of TYR gene family in Ruditapes philippinarum under the challenge of Vibrio anguillarum. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 37, 100788. DOI Link

Wang, J., Zhang, H., Xu, S., Liu, Z., Yang, L., Fang, L., Huo, Z., & Yan, X. (2021). Characterization of the SIRT genes and their distinct expression patterns in Manila clams (Ruditapes philippinarum) exposed to air. Meta Gene, 100892.

Zhao, W.X., Li, Y., Wang, Y., Luo, X., Wu, Q., Huo, Z., Song, J., & Yan, X. (2021). Gonadal development and the reproductive cycle of the geoduck clam (Panopea japonica) in the Sea of Japan. Aquaculture.

Xu, Q., Nie, H., Yin, Z., Zhang, Y., Huo, Z., & Yan, X. (2021). MiRNA-mRNA Integration Analysis Reveals the Regulatory Roles of MiRNAs in Shell Pigmentation of the Manila clam (Ruditapes philippinarum). Marine Biotechnology, 23, 976 - 993.

Li, D., Nie, H., Jahan, K., & Yan, X. (2020). Expression analyses of C-type lectins (CTLs) in Manila clam under cold stress provide insights for its potential function in cold resistance of Ruditapes philippinarum. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 230, 108708. DOI Link

Xu, Q., Zheng, J., Yan, X., & Nie, H. (2020). Genetic diversity and differentiation of nine populations of the hard clam (Meretrix petechialis) assessed by EST-derived microsatellites. Electronic Journal of Biotechnology.

Xu, Q., Zheng, J., Nie, H., Wang, Q., & Yan, X. (2020). Genetic diversity and population structure of Meretrix petechialis in China revealed by sequence-related amplified polymorphism markers. PeerJ, 8, e8723.

Wang, J., Fang, L., Wu, Q., Li, D., Huo, Z., & Yan, X. (2020). Genome-wide identification and characterization of the AMPK genes and their distinct expression patterns in response to air exposure in the Manila clam (Ruditapes philippinarum). Genes & genomics, 42(1), 1–12. DOI Link

Bai, Y., Nie, H., Wang, Z., & Yan, X. (2020). Genome-wide identification and transcriptome-based expression profiling of Wnt gene family in Ruditapes philippinarum. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 35, 100709. DOI Link

Nie, H., Jiang, K., Zhou, Z., Guo, B., Li, D., & Yan, X. (2020). Modulated Expression and Activities of Ruditapes philippinarum Enzymes After Oxidative Stress Induced by Aerial Exposure and Reimmersion. Frontiers in physiology, 11, 500.DOI Link

Li, D., Nie, H., Jiang, K., Li, N., Huo, Z., & Yan, X. (2020). Molecular characterization and expression analysis of fibrinogen related protein (FREP) genes of Manila clam (Ruditapes philippinarum) after lipopolysaccharides challenge. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 228, 108672. DOI Link

Dong, S., Nie, H., Li, D., Cai, Z., Sun, X., Huo, Z., & Yan, X. (2020). Molecular cloning and characterization of Y-box gene (Rpybx) from Manila clam and its expression analysis in different strains under low-temperature stress. Animal genetics, 51(3), 430–438.DOI Link

Jiang, K., Nie, H., & Yan, X. (2020). Molecular cloning and expression analysis of mc5r like genes (mc5rl) in Ruditapes philippinarum (Manila clam) after aerial exposure and low-temperature stress. Molecular biology reports, 47(11), 8891–8901. DOI Link

Jiang, K., Jiang, L., Nie, H., Huo, Z., & Yan, X. (2020). Molecular cloning and expression analysis of tyrosinases (tyr) in four shell-color strains of Manila clam Ruditapes philippinarum. PeerJ, 8, e8641. DOI Link

Jiang, K., Nie, H., Li, D., & Yan, X. (2020). New insights into the Manila clam and PAMPs interaction based on RNA-seq analysis of clam through in vitro challenges with LPS, PGN, and poly(I:C). BMC genomics, 21(1), 531.DOI Link

Nie, H., Jahan, K., Zhang, W., Huo, Z., & Yan, X. (2020). Physiological and biochemical responses of different shell color strains of Manila clam to low salinity challenges. Aquaculture Reports, 16, 100260.

Dong, S., Nie, H., Ye, J., Li, D., Huo, Z., & Yan, X. (2020). Physiological and gene expression analysis of the Manila clam Ruditapes philippinarum in response to cold acclimation. The Science of the total environment, 742, 140427.DOI Link

Tan, Y., Fang, L., Qiu, M. et al. Population genetics of the Manila clam (Ruditapes philippinarum) in East Asia. Sci Rep 10, 21890 (2020). DOI Link

Nie, H., Wang, H., Jiang, K., & Yan, X. (2020). Transcriptome analysis reveals differential immune related genes expression in Ruditapes philippinarum under hypoxia stress: potential HIF and NF-κB crosstalk in immune responses in clam. BMC genomics, 21(1), 318. DOI Link

Nie, H., Jiang, K., Jiang, L., Huo, Z., Ding, J., & Yan, X. (2020). Transcriptome analysis reveals the pigmentation related genes in four different shell color strains of the Manila clam Ruditapes philippinarum. Genomics, 112(2), 2011–2020. DOI Link

Nie, H., Jiang, K., Li, N., Jahan, K., Jiang, L., Huo, Z., & Yan, X. (2021). Transcriptome analysis reveals the pigmentation-related genes in two shell color strains of the Manila clam Ruditapes philippinarum. Animal biotechnology, 32(4), 439–450. DOI Link

Nie H, Jiang K, Li N, Li D, Yan X. Transcriptomic analysis of Ruditapes philippinarum under aerial exposure and reimmersion reveals genes involved in stress response and recovery capacity of the Manila clam Aquaculture.. 2020 Jul;524:Not Available. DOI: 10.1016/j.aquaculture.2020.735271.

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